Quick Answer: Which Type Of Mutation Would Cause The Greatest Effect On A Protein?

Which type of mutation is likely to have the greatest effect on a protein?

Which type of mutation – a base substitution or a base deletion – is most likely to have the greatest effect on the organism.


Base deletion: b/c it can use complete frameshift which will mess up the amino acid sequence —> cause a chain effect of many things getting messed up..

What type of mutation has the greatest effect?

At the short end of the spectrum, indels of one or two base pairs within coding sequences have the greatest effect, because they will inevitably cause a frameshift (only the addition of one or more three-base-pair codons will keep a protein approximately intact).

What type of mutation causes the least damage?

Point MutationsPoint Mutations A point mutation—the change of a single nitrogen base in a DNA sequence—is usually the least harmful type of DNA mutation. Codons are a sequence of three nitrogen bases in a row that are “read” by messenger RNA during transcription.

What is an example of silent mutation?

Silent mutations are base substitutions that result in no change of the amino acid or amino acid functionality when the altered messenger RNA (mRNA) is translated. For example, if the codon AAA is altered to become AAG, the same amino acid – lysine – will be incorporated into the peptide chain.

How does a mutation cause a change in a protein?

Frameshift mutations The outcome of a frameshift mutation is complete alteration of the amino acid sequence of a protein. This alteration occurs during translation because ribosomes read the mRNA strand in terms of codons, or groups of three nucleotides. These groups are called the reading frame.

What causes mutation?

​Mutation. A mutation is a change in a DNA sequence. Mutations can result from DNA copying mistakes made during cell division, exposure to ionizing radiation, exposure to chemicals called mutagens, or infection by viruses.

Which mutation is most likely to destroy protein function?

frameshift mutationsmost: b., because the oncogene product is still functional (often extra functional), and nonsense and frameshift mutations are most likely to destroy the function of the protein; least: d. 15.

What are the two main types of mutations?

Two major categories of mutations are germline mutations and somatic mutations.Germline mutations occur in gametes. These mutations are especially significant because they can be transmitted to offspring and every cell in the offspring will have the mutation.Somatic mutations occur in other cells of the body.

Which type of mutation is most harmful?

1). Because an insertion or deletion results in a frame-shift that changes the reading of subsequent codons and, therefore, alters the entire amino acid sequence that follows the mutation, insertions and deletions are usually more harmful than a substitution in which only a single amino acid is altered.

Which type of mutation has no effect on a protein?

missense mutationA missense mutation is when the change of a single base pair causes the substitution of a different amino acid in the resulting protein. This amino acid substitution may have no effect, or it may render the protein nonfunctional.

Is a deletion a missense mutation?

The types of mutations include: Missense mutation. This type of mutation is a change in one DNA base pair that results in the substitution of one amino acid for another in the protein made by a gene. … A deletion changes the number of DNA bases by removing a piece of DNA.

Which mutation will cause translation to stop?

Thus, nonsense mutations occur when a premature nonsense or stop codon is introduced in the DNA sequence. When the mutated sequence is translated into a protein, the resulting protein is incomplete and shorter than normal. Consequently, most nonsense mutations result in nonfunctional proteins.

What are some examples of beneficial mutations?

Examples of beneficial mutations include HIV resistance, lactose tolerance, and trichromatic vision.

What are the 4 types of mutation?

There are three types of DNA Mutations: base substitutions, deletions and insertions.Base Substitutions. Single base substitutions are called point mutations, recall the point mutation Glu —–> Val which causes sickle-cell disease.Deletions. … Insertions.